TNFRSF13C

Across TCGA pan-cancer cohorts, TNFRSF13C RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of TNFRSF13C’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TNFRSF13C RNA is repressed in tumor relative to normal tissue. In most cancer types TNFRSF13C is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

COAD, LUAD, and LUSC are the cancer types where TNFRSF13C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNFRSF13C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.971	<.001	8	view →
LUAD	Female	All	+1.169	<.001	7	view →
LUSC	All	II,III,IV	+1.229	<.001	5	view →
STAD	Female	All	+1.452	.014	4	view →
UCEC	All	All	+0.664	.006	4	view →
CHOL	All	All	+1.520	.006	2	view →
KIRC	All	All	+0.234	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

TNFRSF13C–COAD

Open the COAD breakdown →