TNFRSF12A

Across TCGA pan-cancer cohorts, TNFRSF12A RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of TNFRSF12A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TNFRSF12A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNFRSF12A is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

HNSC, THCA, and KIRP are the cancer types where TNFRSF12A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNFRSF12A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+2.457	<.001	12	view →
THCA	All	IV	+3.375	<.001	11	view →
KIRP	All	IV	+3.187	<.001	11	view →
COAD	Female	III,IV	+3.059	<.001	11	view →
STAD	Male	II,III,IV	+2.170	<.001	9	view →
KICH	All	II,III,IV	−2.241	<.001	8	view →
LUAD	Female	II,III,IV	+1.066	<.001	6	view →
READ	Male	All	+2.716	.010	5	view →
LIHC	All	II,III,IV	+1.243	.002	5	view →
KIRC	Male	All	+0.905	<.001	5	view →
UCEC	All	All	+1.173	.011	4	view →
BRCA	All	All	+0.848	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

TNFRSF12A–HNSC

Open the HNSC breakdown →