TNFRSF12A

Across TCGA pan-cancer cohorts, TNFRSF12A mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of TNFRSF12A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TNFRSF12A mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TNFRSF12A is over-expressed in tumor.

HNSC, LUAD, and PDAC are the cancer types where TNFRSF12A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNFRSF12A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.848	<.001	11	view →
LUAD	Female	III,IV	+1.168	<.001	9	view →
PDAC	Female	II,III,IV	+0.923	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

TNFRSF12A–HNSC

Open the HNSC breakdown →