TNFRSF11B

Across TCGA pan-cancer cohorts, TNFRSF11B mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TNFRSF11B data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TNFRSF11B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TNFRSF11B expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where TNFRSF11B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	0.628	1.000	.003	22	view →
CCRCC	OS	Median	III,IV	0.727	0.285	.028	4	view →
PDAC	DFS	Median	III,IV	0.257	0.887	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TNFRSF11B–LSCC (OS)

Open the LSCC breakdown →