TNFRSF11B

Across TCGA patient cohorts, TNFRSF11B mutation is significantly associated with the RNA expression of many other genes, with 2,259 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFRSF11B-associated genes across cancer lineages are LINC02438, USP9YP2, and RN7SL134P. Each is linked with TNFRSF11B in more than 2 cancer types. Because this analysis shows association rather than direction, both TNFRSF11B-to-partner and partner-to-TNFRSF11B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02438 grouped by TNFRSF11B-low versus TNFRSF11B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF11B→partner) and Y-score (partner→TNFRSF11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC02438 →	+0.716	+2.353	<.001	.002	3	3
UCEC	USP9YP2 →	+0.010	+4.159	<.001	.003	3	3
UCEC	RN7SL134P →	+0.095	+2.014	<.001	.001	3	3
LGG	RNU6-1119P →	+0.429	+4.321	<.001	.007	3	2
LGG	RPSAP59 →	+0.056	+4.534	<.001	.005	3	2
LGG	PLGLA →	+0.045	+4.562	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,259 associations by consensus.

LINC02438 by TNFRSF11B expression — SKCM

Explore this box plot interactively →