TNFRSF11B

Across TCGA patient cohorts, TNFRSF11B mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFRSF11B-associated genes across cancer lineages are S6_pS240_S244, VHL, and ATM. Each is linked with TNFRSF11B in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF11B-to-partner and partner-to-TNFRSF11B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by TNFRSF11B-low versus TNFRSF11B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF11B→partner) and Y-score (partner→TNFRSF11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.278	+1.440	.048	.024	3	2
UCEC	VHL →	-0.975	-2.169	<.001	.003	3	2
UCEC	ATM →	-0.498	-2.209	.001	.009	3	2
UCEC	cIAP →	+0.100	+1.495	.035	.034	3	2
UCEC	c-Met_pY1235 →	+0.062	+2.257	.016	<.001	3	2
SKCM	Bak →	+0.280	+3.012	.019	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

S6_pS240_S244 by TNFRSF11B expression — UCEC

Explore this box plot interactively →