TNFRSF11B

Across TCGA cell cohorts, TNFRSF11B mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible TNFRSF11B-associated genes across cancer lineages are KRTAP4-6, OR13C7, and CLEC4C. Each is linked with TNFRSF11B in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF11B-to-partner and partner-to-TNFRSF11B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP4-6 grouped by TNFRSF11B-low versus TNFRSF11B-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF11B→partner) and Y-score (partner→TNFRSF11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRTAP4-6 →	+0.107	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR13C7 →	+0.038	+5.369	<.001	.004	3	1
LUNG_SCLC	CLEC4C →	+0.072	+5.029	<.001	.006	3	1
OVARY	OR52L1 →	+0.118	+5.196	<.001	.005	3	1
OVARY	CT45A6 →	+0.072	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

KRTAP4-6 by TNFRSF11B expression — SOFT_TISSUE

Explore this box plot interactively →