TNFRSF10B

Across TCGA pan-cancer cohorts, TNFRSF10B mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TNFRSF10B data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TNFRSF10B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TNFRSF10B expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, PDAC, and LUAD are the cancer types where TNFRSF10B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	1.000	0.198	.008	38	view →
PDAC	DFS	Tertile	All	0.701	0.982	<.001	27	view →
LUAD	OS	Median	All	0.877	0.603	.041	2	view →
HNSC	OS	Quartile	All	1.000	0.682	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TNFRSF10B–UCEC (DFS)

Open the UCEC breakdown →