Across TCGA pan-cancer cohorts, TNFAIP8L3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TNFAIP8L3 data layer compared with 27 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TNFAIP8L3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TNFAIP8L3 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.

COAD, SKCM, and UCEC are the cancer types where TNFAIP8L3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.199	0.785	<.001	27	view →
SKCM	DFS	Median	II,III,IV	0.915	0.663	.019	5	view →
UCEC	DFS	Median	III,IV	1.000	0.544	.044	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TNFAIP8L3 tumor-vs-normal RNA expression · all TNFAIP8L3 data types