Across TCGA pan-cancer cohorts, TNFAIP8L3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TNFAIP8L3 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TNFAIP8L3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TNFAIP8L3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where TNFAIP8L3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	II,III,IV	0.104	0.989	.010	24	view →
PDAC	DFS	Median	III,IV	0.971	0.289	.007	12	view →
LUAD	DFS	Tertile	II,III,IV	0.682	0.989	.005	10	view →
LSCC	DFS	Quartile	II,III,IV	0.888	0.221	.024	5	view →
GBM	OS	Median	All	0.819	0.886	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TNFAIP8L3 tumor-vs-normal RNA expression · all TNFAIP8L3 data types