Across TCGA pan-cancer cohorts, TNFAIP8L1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TNFAIP8L1 data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher TNFAIP8L1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TNFAIP8L1 expression acts as an unfavorable survival marker.

ESCA and CESC are the cancer types where TNFAIP8L1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.102	0.703	<.001	36	view →
CESC	OS	Median	III,IV	0.091	0.755	<.001	24	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: TNFAIP8L1 tumor-vs-normal RNA expression · all TNFAIP8L1 data types