TNFAIP8

Across TCGA pan-cancer cohorts, TNFAIP8 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TNFAIP8 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TNFAIP8 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TNFAIP8 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, CCRCC, and COAD are the cancer types where TNFAIP8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.702	0.347	.002	16	view →
CCRCC	DFS	Tertile	All	0.575	1.000	.009	7	view →
COAD	DFS	Median	IV	0.565	1.000	.028	6	view →
GBM	OS	Tertile	All	0.253	0.511	.017	5	view →
LSCC	DFS	Median	III,IV	0.944	0.635	.031	3	view →
LUAD	DFS	Median	All	0.819	0.662	.009	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TNFAIP8–PDAC (OS)

Open the PDAC breakdown →