TNFAIP8

Across TCGA patient cohorts, TNFAIP8 mutation is significantly associated with the RNA expression of many other genes, with 76 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TNFAIP8-associated genes across cancer lineages are CAMTA1-AS2, MIR3945, and MIR1256. Each is linked with TNFAIP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFAIP8-to-partner and partner-to-TNFAIP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CAMTA1-AS2 grouped by TNFAIP8-low versus TNFAIP8-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFAIP8→partner) and Y-score (partner→TNFAIP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CAMTA1-AS2 →	+0.112	+5.736	<.001	<.001	3	2
SKCM	MIR3945 →	+0.444	+4.979	<.001	.009	3	2
SKCM	MIR1256 →	+0.393	+5.513	<.001	.004	3	2
BRCA	OR5B15P →	+0.085	+7.586	<.001	<.001	3	1
BRCA	MIR6078 →	+0.682	+6.016	<.001	.002	3	1
SKCM	PISRT1 →	+0.138	+5.436	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

CAMTA1-AS2 by TNFAIP8 expression — LUSC

Explore this box plot interactively →