TNFAIP8

Across TCGA cell cohorts, TNFAIP8 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TNFAIP8-associated genes across cancer lineages are TIFAB, OR10A6, and CFHR2. Each is linked with TNFAIP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFAIP8-to-partner and partner-to-TNFAIP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIFAB grouped by TNFAIP8-low versus TNFAIP8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFAIP8→partner) and Y-score (partner→TNFAIP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TIFAB →	+0.006	+4.977	<.001	.007	3	1
BLOOD_Leukemia	OR10A6 →	+0.044	+5.201	<.001	.006	3	1
BLOOD_Leukemia	CFHR2 →	+0.395	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

TIFAB by TNFAIP8 expression — LARGE_INTESTINE

Explore this box plot interactively →