TNF

Across TCGA patient cohorts, TNF mutation is significantly associated with the RNA expression of many other genes, with 131 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TNF-associated genes across cancer lineages are RNU6-1077P, MIR4684, and DPPA5P1. Each is linked with TNF in more than 1 cancer types. Because this analysis shows association rather than direction, both TNF-to-partner and partner-to-TNF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1077P grouped by TNF-low versus TNF-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNF→partner) and Y-score (partner→TNF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-1077P →	+0.603	+4.211	<.001	.009	3	2
LUSC	MIR4684 →	+0.407	+4.548	<.001	.009	3	2
LUSC	DPPA5P1 →	+0.131	+4.978	<.001	.005	3	2
UCEC	RN7SL83P →	+0.233	+3.246	.001	.008	3	2
LUAD	MIR208A →	+0.422	+7.930	<.001	.008	3	2
LUSC	RNU2-14P →	+0.224	+6.102	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 131 associations by consensus.

RNU6-1077P by TNF expression — LUSC

Explore this box plot interactively →