TNF

Across TCGA cell cohorts, TNF mutation is significantly associated with the RNA expression of many other genes, with 1 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNF-associated genes across cancer lineages are MS4A4A. Each is linked with TNF in more than 1 cancer types. Because this analysis shows association rather than direction, both TNF-to-partner and partner-to-TNF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A4A grouped by TNF-low versus TNF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNF→partner) and Y-score (partner→TNF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MS4A4A →	+0.191	+4.000	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 1 strongest of 1 associations by consensus.

MS4A4A by TNF expression — LARGE_INTESTINE

Explore this box plot interactively →