TMX3

Across TCGA patient cohorts, TMX3 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMX3-associated genes across cancer lineages are Notch1, ATM, and eIF4E. Each is linked with TMX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMX3-to-partner and partner-to-TMX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TMX3-low versus TMX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMX3→partner) and Y-score (partner→TMX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.196	+2.662	<.001	<.001	3	2
UCEC	ATM →	-0.532	-1.765	.001	.014	3	2
UCEC	eIF4E →	+0.201	+2.169	.011	.003	3	1
UCEC	A-Raf_pS299 →	-0.094	-2.000	.035	.030	3	1
UCEC	FoxM1 →	+0.243	+2.662	.012	<.001	3	1
UCEC	JNK2 →	+0.258	+3.611	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Notch1 by TMX3 expression — UCEC

Explore this box plot interactively →