TMX3

Across TCGA cell cohorts, TMX3 mutation is significantly associated with the mutation status of many other genes, with 3,320 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMX3-associated genes across cancer lineages are KRT77, SLCO1B3, and RAB35. Each is linked with TMX3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMX3-to-partner and partner-to-TMX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT77 grouped by TMX3-low versus TMX3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMX3→partner) and Y-score (partner→TMX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KRT77 →	+5.894	+5.321	.002	.002	1	4
BLOOD_Leukemia	SLCO1B3 →	+4.309	+4.560	.007	.007	1	3
BLOOD_Leukemia	RAB35 →	+4.894	+4.894	.004	.004	1	3
LARGE_INTESTINE	CHAF1A →	+2.992	+4.767	<.001	<.001	1	3
BLOOD_Leukemia	NELFE →	+4.309	+4.560	.007	.007	1	3
LARGE_INTESTINE	IMPDH1 →	+3.630	+3.630	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,320 associations by consensus.

KRT77 by TMX3 expression — BLOOD_Leukemia

Explore this box plot interactively →