Across TCGA cell cohorts, TMX2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TMX2-associated genes across cancer lineages are NKX2-6, TLE7, and CST9L. Each is linked with TMX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMX2-to-partner and partner-to-TMX2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMX2→partner) and Y-score (partner→TMX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1
LUNG_NSCLC_LUAD	CST9L →	+0.022	+4.947	.001	.001	3	1
LUNG_NSCLC_LUAD	OR10AG1 →	+0.032	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR2AJ1 →	+0.019	+4.734	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR2L13 →	+0.030	+4.212	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

TMX2 survival (RNA) · tumor vs normal (RNA) · all TMX2 data types