TMX1

Across TCGA pan-cancer cohorts, TMX1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TMX1 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMX1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TMX1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LUAD, and GBM are the cancer types where TMX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	1.000	0.905	<.001	23	view →
LUAD	OS	Tertile	All	0.755	0.938	.008	21	view →
GBM	DFS	Tertile	All	0.220	0.505	.025	6	view →
LSCC	OS	Tertile	II,III,IV	0.844	0.472	.014	5	view →
OV	DFS	Quartile	All	0.609	1.000	.037	4	view →
PDAC	DFS	Quartile	All	0.719	0.891	.036	3	view →
CCRCC	OS	Tertile	All	0.719	1.000	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TMX1–HNSC (DFS)

Open the HNSC breakdown →