TMX1

Across TCGA patient cohorts, TMX1 mutation is significantly associated with the RNA expression of many other genes, with 1,105 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMX1-associated genes across cancer lineages are MIR128-2, MIR1263, and RNA5SP328. Each is linked with TMX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMX1-to-partner and partner-to-TMX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR128-2 grouped by TMX1-low versus TMX1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMX1→partner) and Y-score (partner→TMX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR128-2 →	+0.372	+7.924	.001	.008	3	2
COAD	MIR1263 →	+1.494	+7.741	<.001	.009	3	2
SKCM	RNA5SP328 →	+0.206	+5.219	<.001	.002	3	2
COAD	MBD3L3 →	+0.129	+7.741	<.001	.009	3	2
UCEC	RNU6ATAC30P →	+0.338	+2.069	<.001	<.001	3	2
UCEC	BTBD10 →	+0.470	+3.839	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,105 associations by consensus.

MIR128-2 by TMX1 expression — LUSC

Explore this box plot interactively →