TMUB2

Across TCGA patient cohorts, TMUB2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMUB2-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and A-Raf_pS299. Each is linked with TMUB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMUB2-to-partner and partner-to-TMUB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TMUB2-low versus TMUB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMUB2→partner) and Y-score (partner→TMUB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.320	-2.662	<.001	<.001	3	1
UCEC	eIF4E →	+0.182	+2.183	.021	.033	3	1
UCEC	A-Raf_pS299 →	-0.159	-2.584	<.001	.010	3	1
UCEC	ERK2 →	+0.181	+3.459	.012	.005	3	1
UCEC	Fibronectin →	-0.246	-1.415	.046	.046	3	1
UCEC	ACC1 →	+0.353	+2.472	.009	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

EGFR_pY1068 by TMUB2 expression — UCEC

Explore this box plot interactively →