TMTC4

Across TCGA patient cohorts, TMTC4 protein abundance is significantly associated with the RNA expression of many other genes, with 3,031 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible TMTC4-associated genes across cancer lineages are IGHV3-13, COX5BP6, and RASAL3. Each is linked with TMTC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMTC4-to-partner and partner-to-TMTC4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMTC4 versus IGHV3-13 in LUAD, with a Pearson correlation of -0.28.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMTC4→partner) and Y-score (partner→TMTC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IGHV3-13 →	-1.518	-0.341	<.001	<.001	3	3
LSCC	COX5BP6 →	+1.275	+0.711	<.001	<.001	3	3
UCEC	RASAL3 →	-0.536	-0.382	.001	<.001	3	2
LUAD	CD79A →	-1.052	-0.318	.003	.009	3	2
LUAD	SLAMF1 →	-0.595	-0.368	<.001	<.001	3	2
LUAD	DNAL1 →	+0.339	+0.363	.003	.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,031 associations by consensus.

TMTC4 vs IGHV3-13 — LUAD

Explore this scatter interactively →