TMTC4

Across TCGA patient cohorts, TMTC4 mutation is significantly associated with the RNA expression of many other genes, with 4,843 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMTC4-associated genes across cancer lineages are RN7SL478P, RNU6-218P, and MIR615. Each is linked with TMTC4 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMTC4-to-partner and partner-to-TMTC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL478P grouped by TMTC4-low versus TMTC4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMTC4→partner) and Y-score (partner→TMTC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SL478P →	+0.350	+4.683	<.001	.001	3	4
LUAD	RNU6-218P →	+0.587	+2.609	<.001	.004	3	3
SKCM	MIR615 →	+0.318	+2.484	<.001	.005	3	3
BLCA	RPS27P20 →	+0.149	+3.926	.003	.005	3	3
LGG	RNU7-7P →	+0.635	+5.529	<.001	.004	3	2
LGG	MTCO2P4 →	+0.192	+5.679	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,843 associations by consensus.

RN7SL478P by TMTC4 expression — BLCA

Explore this box plot interactively →