TMTC4

Across TCGA patient cohorts, TMTC4 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMTC4-associated genes across cancer lineages are JNK2, MEK1, and eIF4E. Each is linked with TMTC4 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMTC4-to-partner and partner-to-TMTC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by TMTC4-low versus TMTC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMTC4→partner) and Y-score (partner→TMTC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.254	+2.050	<.001	<.001	3	4
UCEC	MEK1 →	+0.440	+4.087	<.001	<.001	3	3
UCEC	eIF4E →	+0.216	+2.321	<.001	<.001	3	2
UCEC	ERK2 →	+0.135	+1.807	.018	.024	3	2
UCEC	FOXO3a_pS318_S321 →	-0.119	-1.584	.001	.007	3	2
UCEC	p53 →	-0.257	-2.000	.025	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

JNK2 by TMTC4 expression — UCEC

Explore this box plot interactively →