TMTC4

Across TCGA cell cohorts, TMTC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,902 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMTC4-associated GO terms across cancer lineages are Ribosomal protein import into nucleus, Post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery, and Copper ion export. Each is linked with TMTC4 in more than 16 cancer types. Because this analysis shows association rather than direction, both TMTC4-to-partner and partner-to-TMTC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ribosomal protein import into nucleus grouped by TMTC4-low versus TMTC4-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMTC4→partner) and Y-score (partner→TMTC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Ribosomal protein import into nucleus →	+0.144	+1.474	<.001	<.001	3	17
LUNG_SCLC	Post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.094	+1.255	.003	<.001	3	14
BLOOD_Leukemia	Copper ion export →	-0.216	-0.920	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of cytoplasmic mRNA processing body assembly →	+0.098	+1.291	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Negative regulation of hematopoietic stem cell differentiation →	+0.118	+0.945	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Positive regulation of double-strand break repair →	+0.077	+1.378	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,902 associations by consensus.

Ribosomal protein import into nucleus by TMTC4 expression — STOMACH

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