TMTC4

Across TCGA cell cohorts, TMTC4 mutation is significantly associated with the RNA expression of many other genes, with 255 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMTC4-associated genes across cancer lineages are SEMG1, SLC5A8, and CBLN4. Each is linked with TMTC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMTC4-to-partner and partner-to-TMTC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEMG1 grouped by TMTC4-low versus TMTC4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMTC4→partner) and Y-score (partner→TMTC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SEMG1 →	+1.086	+2.451	<.001	.009	3	2
PANCREAS	SLC5A8 →	+0.004	+4.029	<.001	.007	3	1
PANCREAS	CBLN4 →	+0.004	+4.029	<.001	.007	3	1
LUNG_SCLC	OR4D10 →	+0.022	+5.029	<.001	.006	3	1
LUNG_NSCLC_LUAD	ZAN →	+0.004	+4.662	<.001	.005	3	1
LARGE_INTESTINE	GCAT →	+1.511	+3.321	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 255 associations by consensus.

SEMG1 by TMTC4 expression — LARGE_INTESTINE

Explore this box plot interactively →