TMTC3

Across TCGA pan-cancer cohorts, TMTC3 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TMTC3’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where TMTC3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TMTC3 is over-expressed in tumor.

CCRCC, LSCC, and HNSC are the cancer types where TMTC3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMTC3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	+0.694	<.001	10	view →
LSCC	Female	All	+1.172	<.001	9	view →
HNSC	All	IV	+0.783	<.001	9	view →
LUAD	Male	All	+0.193	<.001	6	view →
COAD	Female	III,IV	+0.190	.011	3	view →
PDAC	All	II,III,IV	+0.191	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TMTC3–CCRCC

Open the CCRCC breakdown →