TMTC3

Across TCGA patient cohorts, TMTC3 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMTC3-associated genes across cancer lineages are C-Raf, ACC1, and S6_pS240_S244. Each is linked with TMTC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMTC3-to-partner and partner-to-TMTC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by TMTC3-low versus TMTC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMTC3→partner) and Y-score (partner→TMTC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.184	+2.000	<.001	.009	3	2
UCEC	ACC1 →	+0.288	+1.598	.018	.040	3	2
UCEC	S6_pS240_S244 →	+0.379	+2.201	.005	<.001	3	2
UCEC	ASNS →	+0.367	+2.115	.002	.016	3	2
UCEC	14-3-3_beta →	-0.107	-2.295	.001	.005	3	1
UCEC	eIF4E →	+0.201	+2.201	.004	<.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

C-Raf by TMTC3 expression — UCEC

Explore this box plot interactively →