TMTC3

Across TCGA cell cohorts, TMTC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,538 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMTC3-associated GO terms across cancer lineages are Chromosomal 5-methylcytosine DNA demethylation pathway, Negative regulation of cell cycle process, and Vesicle tethering to Golgi. Each is linked with TMTC3 in more than 13 cancer types. Because this analysis shows association rather than direction, both TMTC3-to-partner and partner-to-TMTC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chromosomal 5-methylcytosine DNA demethylation pathway grouped by TMTC3-low versus TMTC3-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMTC3→partner) and Y-score (partner→TMTC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Chromosomal 5-methylcytosine DNA demethylation pathway →	+0.287	+1.283	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle process →	+0.050	+0.758	<.001	<.001	3	13
BONE	Vesicle tethering to Golgi →	+0.116	+1.020	<.001	<.001	3	13
STOMACH	Positive regulation of mRNA processing →	+0.099	+0.926	.002	<.001	3	13
STOMACH	Golgi vesicle transport →	+0.082	+1.114	.001	<.001	3	12
LARGE_INTESTINE	Protein localization to condensed chromosome →	+0.108	+1.120	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,538 associations by consensus.

Chromosomal 5-methylcytosine DNA demethylation pathway by TMTC3 expression — STOMACH

Explore this box plot interactively →