TMTC3

Across TCGA cell cohorts, TMTC3 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMTC3-associated genes across cancer lineages are CCDC60, C1orf146, and TAS2R41. Each is linked with TMTC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMTC3-to-partner and partner-to-TMTC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC60 grouped by TMTC3-low versus TMTC3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMTC3→partner) and Y-score (partner→TMTC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CCDC60 →	+0.064	+4.228	<.001	.006	3	2
OVARY	C1orf146 →	+0.040	+4.450	<.001	.004	3	1
OVARY	TAS2R41 →	+0.033	+4.228	<.001	.006	3	1
OVARY	OR13C5 →	+0.018	+5.339	<.001	<.001	3	1
OVARY	ZPBP →	+0.070	+4.029	<.001	.009	3	1
LARGE_INTESTINE	BAAT →	+0.386	+3.465	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

CCDC60 by TMTC3 expression — OVARY

Explore this box plot interactively →