TMTC2

Across TCGA patient cohorts, TMTC2 protein abundance is significantly associated with the RNA expression of many other genes, with 2,274 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMTC2-associated genes across cancer lineages are TMEM245, ALG2, and ISCA1. Each is linked with TMTC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMTC2-to-partner and partner-to-TMTC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMTC2 versus TMEM245 in HNSC, with a Pearson correlation of -0.77.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMTC2→partner) and Y-score (partner→TMTC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TMEM245 →	-0.727	-0.309	<.001	.004	3	2
HNSC	ALG2 →	-0.797	-0.310	.003	.004	3	2
HNSC	ISCA1 →	-0.564	-0.309	<.001	.004	3	2
LSCC	C1orf220 →	-0.558	-0.586	<.001	<.001	3	2
GBM	CST3 →	+1.245	+0.508	<.001	<.001	3	2
LUAD	GLE1 →	-0.495	-0.424	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,274 associations by consensus.

TMTC2 vs TMEM245 — HNSC

Explore this scatter interactively →