TMTC2

Across TCGA cell cohorts, TMTC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,861 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TMTC2-associated GO terms across cancer lineages are Actin filament-based transport, Regulation of cell communication by electrical coupling, and Glycerophospholipid metabolic process. Each is linked with TMTC2 in more than 8 cancer types. Because this analysis shows association rather than direction, both TMTC2-to-partner and partner-to-TMTC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament-based transport grouped by TMTC2-low versus TMTC2-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMTC2→partner) and Y-score (partner→TMTC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Actin filament-based transport →	+0.124	+0.704	<.001	.004	3	9
LUNG_SCLC	Regulation of cell communication by electrical coupling →	-0.154	-1.315	<.001	.002	3	8
PANCREAS	Glycerophospholipid metabolic process →	+0.040	+1.074	.002	.004	3	8
UPPER_AERODIGESTIVE_TRACT	ER-nucleus signaling pathway →	+0.085	+0.891	.007	.001	3	8
LARGE_INTESTINE	Oocyte growth →	+0.159	+0.945	<.001	.002	3	7
LUNG_NSCLC_LUSC	Regulation of mesenchymal stem cell proliferation →	-0.209	-1.461	.006	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,861 associations by consensus.

Actin filament-based transport by TMTC2 expression — KIDNEY

Explore this box plot interactively →