TMTC2

Across TCGA cell cohorts, TMTC2 mutation is significantly associated with the RNA expression of many other genes, with 578 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMTC2-associated genes across cancer lineages are CAPSL, RPL10L, and ITIH3. Each is linked with TMTC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMTC2-to-partner and partner-to-TMTC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CAPSL grouped by TMTC2-low versus TMTC2-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMTC2→partner) and Y-score (partner→TMTC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CAPSL →	+0.061	+3.906	.003	.009	3	2
UPPER_AERODIGESTIVE_TRACT	RPL10L →	+1.674	+4.239	<.001	<.001	3	2
SKIN	ITIH3 →	+0.696	+3.082	.009	.007	3	2
SKIN	TRIM10 →	+0.018	+2.624	.008	.003	3	2
LUNG_NSCLC_LUAD	SLC17A2 →	+0.012	+5.266	<.001	.001	3	2
BLOOD_Lymphoma	POTEM →	+0.321	+4.321	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 578 associations by consensus.

CAPSL by TMTC2 expression — BLOOD_Myeloma

Explore this box plot interactively →