TMTC1

Across TCGA cell cohorts, TMTC1 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible TMTC1-associated genes across cancer lineages are TLX3, HNRNPCL4, and OR9G1. Each is linked with TMTC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMTC1-to-partner and partner-to-TMTC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TLX3 grouped by TMTC1-low versus TMTC1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMTC1→partner) and Y-score (partner→TMTC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TLX3 →	+0.715	+3.523	<.001	.009	3	1
URINARY_TRACT	HNRNPCL4 →	+0.028	+3.584	.002	.009	3	1
BREAST	OR9G1 →	+0.020	+5.781	<.001	.001	3	1
BLOOD_Lymphoma	MC2R →	+0.023	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP10-6 →	+0.022	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	CCER1 →	+0.039	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

TLX3 by TMTC1 expression — URINARY_TRACT

Explore this box plot interactively →