TMSB4Y

Across TCGA pan-cancer cohorts, TMSB4Y RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of TMSB4Y’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TMSB4Y RNA is repressed in tumor relative to normal tissue. In most cancer types TMSB4Y is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and KIRP are the cancer types where TMSB4Y tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMSB4Y RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	IV	−3.323	<.001	7	view →
KIRC	Male	All	−1.294	<.001	7	view →
KIRP	Male	All	−1.824	<.001	6	view →
HNSC	Male	II,III,IV	−0.771	.008	3	view →
STAD	Male	All	−0.613	.003	3	view →
BLCA	Male	IV	−1.722	.033	2	view →
THCA	Male	III,IV	−0.834	.005	2	view →
CHOL	Male	All	+1.161	.020	1	view →
LIHC	Male	All	+0.332	.021	1	view →
ESCA	Female	All	−0.040	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

TMSB4Y–KICH

Open the KICH breakdown →