Across TCGA pan-cancer cohorts, TMSB4XP3 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of TMSB4XP3’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where TMSB4XP3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMSB4XP3 is over-expressed in tumor.
THCA and BRCA are the cancer types where TMSB4XP3 tumor–normal differential expression is most reproducible.