Across TCGA pan-cancer cohorts, TMSB4X mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TMSB4X data layer compared with 20 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMSB4X mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMSB4X expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where TMSB4X mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.531	0.747	.008	20	view →
CCRCC	OS	Quartile	II,III,IV	1.000	0.653	.002	12	view →
LUAD	OS	Median	II,III,IV	0.908	0.339	.003	6	view →
GBM	OS	Median	All	0.383	0.652	.009	4	view →
LSCC	OS	Median	II,III,IV	0.884	1.000	.021	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TMSB4X tumor-vs-normal RNA expression · all TMSB4X data types