TMSB15A

Across TCGA pan-cancer cohorts, TMSB15A Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TMSB15A data layer compared with 24 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher TMSB15A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TMSB15A expression acts as an unfavorable survival marker.

ESCA, COAD, and BRCA are the cancer types where TMSB15A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.212	0.686	.008	30	view →
COAD	OS	Median	All	0.111	0.871	<.001	24	view →
BRCA	OS	Median	All	0.117	0.578	.005	24	view →
STAD	OS	Median	II,III,IV	0.215	0.676	.011	24	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TMSB15A–ESCA (OS)

Open the ESCA breakdown →