TMPRSS9

Across TCGA cell cohorts, TMPRSS9 mutation is significantly associated with the RNA expression of many other genes, with 461 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMPRSS9-associated genes across cancer lineages are S100G, C1orf141, and PSKH2. Each is linked with TMPRSS9 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPRSS9-to-partner and partner-to-TMPRSS9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S100G grouped by TMPRSS9-low versus TMPRSS9-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS9→partner) and Y-score (partner→TMPRSS9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	S100G →	+0.501	+4.680	<.001	<.001	3	2
BREAST	C1orf141 →	+0.049	+5.781	<.001	.001	3	2
CNS	PSKH2 →	+0.032	+4.044	<.001	.003	3	1
SKIN	OR2D3 →	+0.057	+4.510	<.001	.001	3	1
SKIN	KIF19 →	+0.028	+3.793	<.001	.007	3	1
LARGE_INTESTINE	ANKRD54 →	+0.549	+2.451	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 461 associations by consensus.

S100G by TMPRSS9 expression — OVARY

Explore this box plot interactively →