TMPRSS7

Across TCGA patient cohorts, TMPRSS7 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPRSS7-associated genes across cancer lineages are PDCD4, Cyclin-B1, and EGFR_pY1068. Each is linked with TMPRSS7 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMPRSS7-to-partner and partner-to-TMPRSS7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by TMPRSS7-low versus TMPRSS7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS7→partner) and Y-score (partner→TMPRSS7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.434	-1.492	.003	.027	3	3
UCEC	Cyclin-B1 →	+0.635	+2.058	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.214	-1.777	.007	.002	3	2
UCEC	eIF4E →	+0.168	+2.169	.012	.003	3	2
UCEC	FoxM1 →	+0.185	+1.523	.024	.008	3	2
UCEC	Notch1 →	+0.160	+2.183	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

PDCD4 by TMPRSS7 expression — UCEC

Explore this box plot interactively →