TMPRSS7

Across TCGA cell cohorts, TMPRSS7 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,650 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TMPRSS7-associated GO terms across cancer lineages are Response to topologically incorrect protein, Response to unfolded protein, and Regulation of ruffle assembly. Each is linked with TMPRSS7 in more than 9 cancer types. Because this analysis shows association rather than direction, both TMPRSS7-to-partner and partner-to-TMPRSS7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to topologically incorrect protein grouped by TMPRSS7-low versus TMPRSS7-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS7→partner) and Y-score (partner→TMPRSS7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Response to topologically incorrect protein →	+0.076	+0.151	.004	.002	2	10
BREAST	Response to unfolded protein →	+0.075	+0.036	<.001	.002	2	10
LUNG_NSCLC_LUAD	Regulation of ruffle assembly →	+0.102	+0.065	.003	.003	3	8
STOMACH	Response to tumor necrosis factor →	+0.041	+0.135	.007	.008	3	7
OESOPHAGUS	'de novo' IMP biosynthetic process →	-0.143	-0.128	.004	.009	3	7
OESOPHAGUS	Positive regulation of protein localization to membrane →	+0.081	+0.113	<.001	.002	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,650 associations by consensus.

Response to topologically incorrect protein by TMPRSS7 expression — STOMACH

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