TMPRSS7

Across TCGA cell cohorts, TMPRSS7 mutation is significantly associated with the RNA expression of many other genes, with 445 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMPRSS7-associated genes across cancer lineages are PRAMEF17, OR8B4, and OR4X2. Each is linked with TMPRSS7 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPRSS7-to-partner and partner-to-TMPRSS7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF17 grouped by TMPRSS7-low versus TMPRSS7-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS7→partner) and Y-score (partner→TMPRSS7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PRAMEF17 →	+0.014	+4.369	<.001	.008	3	2
OVARY	OR8B4 →	+0.012	+4.222	<.001	.006	3	2
UPPER_AERODIGESTIVE_TRACT	OR4X2 →	+0.065	+4.357	<.001	.006	3	2
LUNG_SCLC	PRAMEF20 →	+0.367	+4.269	<.001	.005	3	2
SKIN	POU4F2 →	+0.484	+3.584	<.001	.007	3	2
SOFT_TISSUE	FTMT →	+0.065	+4.977	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 445 associations by consensus.

PRAMEF17 by TMPRSS7 expression — SOFT_TISSUE

Explore this box plot interactively →