Across TCGA patient cohorts, TMPRSS6 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,558 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TMPRSS6-associated proteins across cancer lineages are CERS2, GMDS_S14, and ARFGEF1. Each is linked with TMPRSS6 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMPRSS6-to-partner and partner-to-TMPRSS6 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS6→partner) and Y-score (partner→TMPRSS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CERS2 →	+0.723	+1.038	<.001	<.001	3	4
COAD	GMDS_S14 →	-0.549	-0.270	.004	.002	3	3
BRCA	ARFGEF1 →	+0.344	+1.093	.006	<.001	3	3
OV	CUX1_S1216 →	+2.006	+2.486	<.001	.003	3	3
OV	GMDS →	-0.445	-0.978	<.001	<.001	3	3
LSCC	MAPRE3 →	+0.392	+0.270	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,558 associations by consensus.

Exploration

TMPRSS6 survival (RNA) · tumor vs normal (RNA) · all TMPRSS6 data types