Across TCGA patient cohorts, TMPRSS6 mutation is significantly associated with the RNA expression of many other genes, with 1,645 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPRSS6-associated genes across cancer lineages are ZWINT, RNA5SP256, and CHAF1A. Each is linked with TMPRSS6 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMPRSS6-to-partner and partner-to-TMPRSS6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS6→partner) and Y-score (partner→TMPRSS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZWINT →	+0.598	+2.197	.005	.009	3	4
CESC	RNA5SP256 →	+0.313	+4.060	.001	.004	3	3
UCEC	CHAF1A →	+0.487	+2.700	.004	.006	3	3
UCEC	ALDH18A1 →	+0.398	+3.617	.009	.001	3	3
SKCM	HELLS →	+0.549	+3.472	.001	.002	3	3
SKCM	GOT1 →	+0.402	+2.201	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,645 associations by consensus.

Exploration

TMPRSS6 survival (RNA) · tumor vs normal (RNA) · all TMPRSS6 data types