Across TCGA cell cohorts, TMPRSS6 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMPRSS6-associated genes across cancer lineages are SPATA31D1, ZPBP2, and TTLL8. Each is linked with TMPRSS6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPRSS6-to-partner and partner-to-TMPRSS6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS6→partner) and Y-score (partner→TMPRSS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPATA31D1 →	+0.387	+3.289	<.001	.009	3	2
LUNG_NSCLC_LUAD	ZPBP2 →	+0.482	+3.145	<.001	.002	3	2
LARGE_INTESTINE	TTLL8 →	+0.002	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR52H1 →	+0.032	+3.669	<.001	<.001	3	1
LARGE_INTESTINE	ELOA3DP →	+0.022	+3.103	<.001	.004	3	1
LARGE_INTESTINE	OR6Q1 →	+0.012	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

TMPRSS6 survival (RNA) · tumor vs normal (RNA) · all TMPRSS6 data types