TMPRSS5

Across TCGA patient cohorts, TMPRSS5 protein abundance is significantly associated with the RNA expression of many other genes, with 107 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMPRSS5-associated genes across cancer lineages are SULT2A1, BCAT2, and WRAP73. Each is linked with TMPRSS5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPRSS5-to-partner and partner-to-TMPRSS5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMPRSS5 versus SULT2A1 in GBM, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS5→partner) and Y-score (partner→TMPRSS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SULT2A1 →	+0.046	+0.416	.003	.001	3	1
GBM	BCAT2 →	-0.920	-0.523	<.001	.005	3	1
GBM	WRAP73 →	-0.490	-0.560	<.001	<.001	3	1
GBM	FAM210B →	-0.594	-0.391	.001	.006	3	1
GBM	TNFSF14 →	+1.148	+0.350	.005	.007	3	1
GBM	MAP7D3 →	-0.456	-0.469	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 107 associations by consensus.

TMPRSS5 vs SULT2A1 — GBM

Explore this scatter interactively →