TMPRSS5

Across TCGA patient cohorts, TMPRSS5 protein abundance is significantly associated with the protein abundance of many other proteins, with 931 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMPRSS5-associated proteins across cancer lineages are URB1_S9, USP7_S963, and VPS13D_S2434. Each is linked with TMPRSS5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPRSS5-to-partner and partner-to-TMPRSS5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMPRSS5 versus URB1_S9 in GBM, with a Pearson correlation of 0.55.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS5→partner) and Y-score (partner→TMPRSS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	URB1_S9 →	+0.541	+0.503	<.001	<.001	3	1
GBM	USP7_S963 →	+0.638	+0.540	.002	.004	3	1
GBM	VPS13D_S2434 →	+0.530	+0.543	<.001	<.001	3	1
GBM	WRNIP1_S151 →	-0.736	-0.347	.002	.003	3	1
GBM	ZC3HC1_S359 →	-0.805	-0.484	<.001	<.001	3	1
GBM	ZNF423_S608 →	+0.724	+0.504	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 931 associations by consensus.

TMPRSS5 vs URB1_S9 — GBM

Explore this scatter interactively →