TMPRSS5

Across TCGA patient cohorts, TMPRSS5 mutation is significantly associated with the RNA expression of many other genes, with 444 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPRSS5-associated genes across cancer lineages are CRYGA, CDRT15P2, and RNU2-62P. Each is linked with TMPRSS5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPRSS5-to-partner and partner-to-TMPRSS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYGA grouped by TMPRSS5-low versus TMPRSS5-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS5→partner) and Y-score (partner→TMPRSS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CRYGA →	+0.105	+6.112	<.001	.002	3	2
LUAD	CDRT15P2 →	+0.106	+5.798	<.001	.003	3	2
UCEC	RNU2-62P →	+0.193	+2.224	.009	.004	3	2
SCLC	GYPB →	+0.153	+5.189	<.001	.006	3	1
SCLC	ASIC5 →	+0.053	+6.228	<.001	.001	3	1
BRCA	RNA5SP534 →	+0.625	+6.639	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 444 associations by consensus.

CRYGA by TMPRSS5 expression — BRCA

Explore this box plot interactively →