TMPRSS5

Across TCGA patient cohorts, TMPRSS5 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPRSS5-associated genes across cancer lineages are Bak, Ku80, and Caspase-7-cleavedD198. Each is linked with TMPRSS5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPRSS5-to-partner and partner-to-TMPRSS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bak grouped by TMPRSS5-low versus TMPRSS5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS5→partner) and Y-score (partner→TMPRSS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bak →	+0.273	+2.584	.015	.010	3	2
UCEC	Ku80 →	+0.329	+2.013	.002	.018	3	1
UCEC	Caspase-7-cleavedD198 →	+0.578	+3.169	.030	.018	3	1
UCEC	Cyclin-E2 →	+0.158	+2.179	.037	.034	3	1
UCEC	P-Cadherin →	-0.130	-3.159	.045	.019	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Bak by TMPRSS5 expression — UCEC

Explore this box plot interactively →